The illustration work of faculty member Jennifer “Jeni” Fairman is featured on the July 13th, 2022 cover of Chemical Reviews.
The cover summarizes the feature article, “Recent Advances in Microscale Electroporation.”
Electroporation (EP) is commonly used to increase cell permeability for reversible intracellular cargo delivery or irreversible cell membrane disruption. In recent years, EP performance has been improved by shrinking electrodes and device structures to the microscale. Integration with microfluidics has led to the design of devices performing static EP, where cells are fixed in a defined region, or continuous EP, where cells are constantly flowing through the device. Each device type offers abilities superior to conventional, macroscale EP devices while providing additional advantageous in precision treatments (static EP) and increased throughput (continuous EP). Microscale EP is gentle on cells and has enabled more sensitive assaying of cells with novel applications. In this review, we present the physical principles of microscale EP devices and examine advances in their design in recent years. In addition, we discuss the applications of the reversible and irreversible EP in the field of development of therapeutics and in the analysis of intracellular contents, among other noteworthy applications. This review aims to encourage scientists and engineers to expand the use of efficient and versatile microscale EP technologies.
Jeni worked with Drs. Sung-Eun Choi, Harrison Khoo and Soojung Claire Hur in the Department of Mechanical Engineering at the Johns Hopkins University.
She used ZBrush, Adobe Illustrator and Photoshop for building and rendering of this piece.
Full citation: Sung-Eun Choi, Harrison Khoo, and Soojung Claire Hur, Recent Advances in Microscale Electroporation, Chemical Reviews,2022 122 (13), 11247-11286, DOI: 10.1021/acs.chemrev.1c00677
